LSD-25, more commonly known as simply LSD, is a powerful psychedelic drug first synthesized by Albert Hofmann in 1938. While LSD is primarily used recreationally, people use LSD for several reasons: augmenting creativity, treating anxiety and clinical depression, and assisting psychotherapy.


An LSD trip lasts 8-12 hours. While effects vary depending on the individual and setting, it is common to see patterns in ordinary objects, feel that sound and light are intensified, and feel euphoria or childlike wonder. The effects of LSD are significantly determined by your pre-trip mental state; it’s important to take steps to make your self comfortable and soothed before the trip.


LSD can be found in several forms. However, LSD is most commonly found dried onto a small squares of paper called “blotters”, and consumed by placing the blotter on the tongue. At moderate dosages of 100 – 150 μg, LSD can produce a psychedelic experience lasting 6 – 12 hours.

Street LSD is often found severely deteriorated due to poor storage conditions. It is important to store LSD properly.

As with most psychedelics, psychonauts can develop tolerance to LSD if they fail to take off sufficient time between trips. To some extent, cross-tolerance with other psychedelics such as psilocybin is also possible.

Comparison with Psilocybin

LSD and psilocybin share many similarities, but also have some subtle differences. The primary difference is that LSD produces a longer psychedelic experience than does psilocybin. There are also anecdotal reports of LSD being less “introspective” than magic mushrooms, but there’s little theoretical basis for such claims.


LSD is classified as a Schedule 1 controlled substance. In particular, this means that it is illegal to both possess and sell in most countries, including the United States. However, the illegality of LSD has little to do with risks of consuming LSD. Instead, LSD’s classification as a Schedule 1 controlled substance is largely politically motivated.

Despite LSD’s illegality, several analogs of LSD such as 1P-LSD, 1A-LSD/ALD-52, 1B-LSD and AL-LAD can be legally purchased for research purposes. When consumed, these LSD analogs produces a virtually identical effect to LSD-25. While LSD analogs can be legally purchased for research purposes, it remains illegal to consume LSD analogs. Practically, however, people often purchase LSD analogs as a less legally risky method of consuming LSD.


LSD has no known lethal dose. Deaths due to LSD occur either due to users consuming LSD in unsafe environments, or because of the accidental consumption of other research chemicals disguised as LSD. Recently, a particular research chemical called 25I-NBOMe has often been found disguised as LSD-25.

High dosages of psychedelics can lead to serotonin syndrome, an overloading of serotonin receptors which may have severe side effects. The risk of serotonin syndrome is low for LSD relative to MDMA, but it’s still possible with very high doses. Serotonin syndrome is more likely if you consume psychedelics while on SSRIs, because SSRIs act on the same serotonin receptors as do psychedelics.